[HTML][HTML] Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches …
Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the
axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast …
axon 18–21 position, have been linked to a variety of cancers, including ovarian, breast …
Epidermal growth factor receptor (EGFR) structure‐based bioactive pharmacophore models for identifying next‐generation inhibitors against clinically relevant EGFR …
Present work elucidates identification of next generation inhibitors for clinically relevant
mutations of epidermal growth factor receptor (EGFR) using structure‐based bioactive …
mutations of epidermal growth factor receptor (EGFR) using structure‐based bioactive …
[HTML][HTML] Computational virtual screening and structure-based design of some epidermal growth factor receptor inhibitors
Background The foremost cause of cancer mortality worldwide was lung cancer. Lung
cancer is divided into small cell lung cancer and non-small cell lung cancer (NSCLC). The …
cancer is divided into small cell lung cancer and non-small cell lung cancer (NSCLC). The …
[HTML][HTML] Fused in silico and bioactivity evaluation method for drug discovery: T001-10027877 was identified as an antiproliferative agent that targets EGFRT790M/C797S/L858R …
L Wang, X Huang, S Xu, Y An, X Lv, W Zhu, S Xu, Y Tu… - BMC chemistry, 2024 - Springer
Background Facing the significant challenge of overcoming drug resistance in cancer
treatment, particularly resistance caused by mutations in epidermal growth factor receptor …
treatment, particularly resistance caused by mutations in epidermal growth factor receptor …
[HTML][HTML] In silico identification of potent small molecule inhibitors targeting epidermal growth factor receptor 1
Z Shi, J Chen, X Guo, L Cheng, X Guo… - Journal of Cancer …, 2018 - journals.lww.com
Background: The receptor tyrosine kinase of the epidermal growth factor receptor (EGFR,
ErbB) family played an important role in multisignaling pathways, which controlled …
ErbB) family played an important role in multisignaling pathways, which controlled …
Exploration of potential EGFR inhibitors: a combination of pharmacophore-based virtual screening, atom-based 3D-QSAR and molecular docking analysis
A Sudha, P Srinivasan… - Journal of Receptors and …, 2015 - Taylor & Francis
Epidermal growth factor receptor (EGFR) protein tyrosine kinases are over expressed in
several human cancers and considered as a promising target for developing novel …
several human cancers and considered as a promising target for developing novel …
[HTML][HTML] In Silico Exploration of Novel EGFR Kinase Mutant-Selective Inhibitors Using a Hybrid Computational Approach
MAA Noor, MM Haq, MAR Chowdhury, H Tayara… - Pharmaceuticals, 2024 - mdpi.com
Targeting epidermal growth factor receptor (EGFR) mutants is a promising strategy for
treating non-small cell lung cancer (NSCLC). This study focused on the computational …
treating non-small cell lung cancer (NSCLC). This study focused on the computational …
[HTML][HTML] Identification of New EGFR Inhibitors by Structure-Based Virtual Screening and Biological Evaluation
S Wang, X Xu, C Pan, Q Guo, Q Li, S Wan, Z Li… - International Journal of …, 2024 - mdpi.com
Epidermal growth factor receptor (EGFR) inhibitors have been used in clinical for the
treatment of non-small-cell lung cancer for years. However, the emergence of drug …
treatment of non-small-cell lung cancer for years. However, the emergence of drug …
Identification of EGFR inhibitors as potential agents for cancer therapy: pharmacophore-based modeling, molecular docking, and molecular dynamics investigations
MA Ashiru, SO Ogunyemi, OR Temionu… - Journal of Molecular …, 2023 - Springer
Context As a member of a large family of proteins that together regulate various aspects of
cell growth and development, the epidermal growth factor receptor (EGFR) is a validated …
cell growth and development, the epidermal growth factor receptor (EGFR) is a validated …
[HTML][HTML] Bioinformatics-driven discovery of novel EGFR kinase inhibitors as anti-cancer therapeutics: In silico screening and in vitro evaluation
Epidermal growth factor receptor EGFR inhibitors are widely used as first line therapy for the
treatment of non-small-cell lung cancer (NSCLC) in patients harboring EGFR mutation …
treatment of non-small-cell lung cancer (NSCLC) in patients harboring EGFR mutation …