Tumor-targeted near-infrared fluorescent dyes have the potential to improve cancer surgery
by enabling surgeons to locate and resect more malignant lesions where good visualization …

Complete surgical resection of malignant disease is the only reliable method to cure cancer.
Unfortunately, quantitative tumor resection is often limited by a surgeon's ability to locate all …

Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Small-molecular targeted probes for biological imaging can be effective for overcoming in
vivo delivery barriers often encountered by large affinity molecules such as monoclonal …

Background Tumor proliferation often occurs from pathologic receptor upregulation. These
receptors provide unique targets for near-infrared (NIR) probes that have fluorescence …

Purpose Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to
improve real-time cancer nodule detection and tumor margin visualization. Currently, the …

Because the most reliable therapy for cancer involves quantitative resection of all diseased
tissue, considerable effort has been devoted to improving a surgeon's ability to locate and …

Molecular fluorescence-guided surgery using near-infrared light has the potential to improve
the rate of complete resection of cancer. Typically, monoclonal antibodies are being used as …

Near-infrared (NIR) fluorescence imaging has attracted much attention in image-guided
interventions with unique advantages. However, the clinical translation rate of fluorescence …

Molecular imaging using near-infrared (NIR) fluorescence is useful for intraoperative
imaging and real-time margin identification. Directly conjugated IR dyes possess useful …