Aberrant anion secretion across the bronchial epithelium is associated with airway disease,
most notably in cystic fibrosis. Although the cystic fibrosis transmembrane conductance …

Defective cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-mediated Cl−
transport across the apical membrane of airway epithelial cells is implicated in the …

Aberrant HCO 3− transport is a hallmark of cystic fibrosis (CF) and is associated with
aberrant Cl−-dependent HCO 3− transport by the cystic fibrosis transmembrane …

SLC6A14-mediated l-arginine transport has been shown to augment the residual anion
channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract. It is …

Thickening of airway mucus and lung dysfunction in cystic fibrosis (CF) results, at least in
part, from abnormal secretion of Cl− and HCO3− across the tracheal epithelium. The …

SLC26A9 is an epithelial anion transporter with a poorly defined function in airways. It is
assumed to contribute to airway chloride secretion and airway surface hydration. However …

Chloride absorption and bicarbonate secretion are vital functions of epithelia,,,,,, as
highlighted by cystic fibrosis and diseases associated with mutations in members of the …

Without cystic fibrosis transmembrane conductance regulator–mediated (CFTR-mediated)
HCO3–secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an …

Cystic fibrosis (CF) is caused by mutations in the gene producing the cystic fibrosis
transmembrane conductance regulator (CFTR). CFTR functions as a Cl− channel. Its …

SLC26 proteins function as anion exchangers and Cl− channels. SLC26A9 has been
proposed to be a constitutively active and CFTR‐regulated anion conductance in human …