Periciliary fluid balance is maintained by the coordination of sodium and chloride channels
in the apical membranes of the airways. In the absence of the cystic fibrosis transmembrane …

SLC26 family members are anionic transporters involved in Cl-and HCO3-absorption or
secretion in epithelia. SLC26A9, preferentially expressed in the lung, is a poorly …

New research reveals a reciprocal regulation between the CFTR chloride channel,
implicated in cystic fibrosis, and several members of the SLC26 family of chloride …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Background and purpose: Calu‐3 cells are derived from serous cells of human lung
submucosal glands, a prime target for therapy in cystic fibrosis (CF). Calu‐3 cells can be …

Chloride transport is critical to many functions of the lung. Molecular defects in the best-
known chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR), lead …

In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR)
channel lead to an acidic airway surface liquid (ASL), which compromises innate defence …

Mucus production is a cardinal feature of bronchial asthma, contributing to morbidity and
mortality in the disease. Goblet cells are major mucus-producing cells, and goblet cell …

Vitamin C (l-ascorbate) is present in the respiratory lining fluid of human lungs, and local
deficits occur during oxidative stress. Here we report a unique function of vitamin C on the …

Multiple sodium and chloride channels on the apical surface of nasal epithelial cells
contribute to periciliary fluid homeostasis, a function that is disrupted in patients with cystic …