The expression of cystic fibrosis transmembrane conductance regulator (CFTR) in
lymphocytes has been reported for nearly two decades; however, its physiological role …

Since the discovery of Cl− impermeability in cystic fibrosis (CF) and the cloning of the
responsible channel, CF pathology has been widely attributed to a defect in epithelial Cl …

Abstract Background/Aims: Patients with cystic fibrosis (CF) are prone to the development of
metabolic alkalosis; however, the pathogenesis of this life threatening derangement remains …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …

Cystic fibrosis (CF) is a genetic disease characterized by the lack of cystic fibrosis
transmembrane conductance regulator (CFTR) protein expressed in epithelial cells. The …

Calcium mobilization can regulate a wide range of essential functions of respiratory
epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of …

Objective: The aim of this study is to evaluate the role of pendrin in acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS) and to explore whether pendrin …

Cigarette smoking causes acquired cystic fibrosis transmembrane conductance regulator
(CFTR) dysfunction and is associated with delayed mucociliary clearance and chronic …

Despite the importance of airway surface liquid pH in the lung's defenses against infection,
the mechanism of airway HCO3− secretion remains unclear. Our aim was to assess the …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that
is defective in cystic fibrosis, and has also been closely associated with ATP permeability in …