The solute carrier family 26, member 9 (SLC26A9) is an epithelial chloride channel that is
expressed in several organs affected in patients with cystic fibrosis (CF) including the lungs …

Host-derived succinate accumulates in the airways during bacterial infection. Here, we show
that luminal succinate activates murine tracheal brush (tuft) cells through a signaling …

Recent studies identified the SLC26A9 Cl− channel as a modifier and potential therapeutic
target in cystic fibrosis (CF). However, understanding of the regulation of SLC26A9 in …

Chronic obstructive pulmonary disease affects 64 million people and is currently the fourth
leading cause of death worldwide. Chronic obstructive pulmonary disease includes both …

Abstract Background and Aims: The thiazide-sensitive Na+-Cl-cotransporter NCC and the Cl-
/HCO 3-exchanger pendrin are expressed on apical membranes of distal cortical nephron …

Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl–channel
expressed in luminal membranes of secretory and reabsorptive epithelia. CFTR plays a …

Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory
chloride/bicarbonate channel in airways and intestine that is activated through ATP binding …

The lungs and kidneys are pivotal organs in the regulation of body acid–base homeostasis.
In cystic fibrosis (CF), the impaired renal ability to excrete an excess amount of HCO3− into …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The activity of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) can be
mediated by surface G protein–coupled receptors such as the β2-adrenergic receptor. In this …