Growing evidence indicates that silibinin (SLB), a main component extracted from Chinese
herb Silybum marianum, can effectively antagonize doxorubicin (DOX) induced myocardial …

Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from
Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of …

Background Doxorubicin (DOX) is a widely used antitumor drug. However, its clinical
application is limited for its serious cardiotoxicity. The mechanism of DOX-induced …

Terminally differentiated adult injured cardiac myocytes have been used for various animal
models of heart failure. It has recently been shown that isoproterenol induces injury in rat …

Lapatinib (LAP) is an important anti-cancer drug and is frequently alongside doxorubicin
(DOX) as a combination therapy for better anti-cancer efficacy. However, many studies have …

Silibinin is a polyphenolic flavanoid derived from fruits and seeds of milk thistle (Silybum
marianum). To investigate the effect and mechanism of silibinin on beta-isoproterenol …

Background Doxorubicin-induced myocardiopathy is a massive obstacle in administering
chemotherapeutic drugs in cancer patients. Purposes In the present study, we aim to …

Doxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However,
treatment with DOX is associated with cumulative cardiotoxicity inducing progressive …

Background Silibinin, a biologically active compound of milk thistle, has chemopreventive
effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth …

Abstract The traditional Chinese medicine Danshensu (DSS) has a protective effect on
cardiac ischaemia/reperfusion (I/R) injury. However, the molecular mechanisms underlying …