The mutator phenotype has been linked in several bacterial genera to a defect in the methyl-
mismatch repair system, in which the major components are MutS and MutL. This system is …

The mutS gene product of Escherichia coli and Salmonella typhimurium is one of at least
four proteins required for methyl-directed mismatch repair in these organisms. A functionally …

Deficiencies in the MutS protein disrupt methyl-directed mismatch repair (MMR), generating
a mutator phenotype typified by high mutation rates and promiscuous recombination. How …

The Bacillus subtilis mutS and mutL genes, involved in the DNA mismatch repair system,
have been cloned and characterized. From sequence analysis the two genes appear to be …

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutS Δ 800)
in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not …

In prokaryotic mismatch repair the MutS protein and its homologs recognize the mismatches.
The mutS gene of naturally transformable Pseudomonas stutzeri ATCC 17587 (genomovar …

Homologs of the Escherichia coli (mutL, S and uvrD) and Streptococcus pneumoniae (hexA,
B) genes involved in mismatch repair are known in several distantly related organisms …

The mismatch repair system is involved in the maintenance of genomic integrity by editing
DNA replication and recombination. However, although most mutations are neutral or …

Populations defective in mismatch repair that exhibit elevated mutation frequencies to
antibiotic resistance have been reported amongst pathogenic Gram-negative bacteria …

ABSTRACT mutS mutators accelerate the bacterial mutation rate 100-to 1,000-fold and relax
the barriers that normally restrict homeologous recombination. These mutators thus afford …