CD4+ helper T cells are critical for protective immune responses and yet suboptimally
primed in response to tumors. Cell-based vaccination strategies are under evaluation in …

Because APCs play a crucial role in the generation of T cell-mediated immune responses,
numerous clinical trials with APC-based vaccines have been initiated in different types of …

Cytotoxic CD8 T cells are key effectors in the immunotherapy of malignant and viral
diseases. However, the lack of efficient methods for their in vitro priming and expansion has …

The production and wide use of artificial antigen presenting cells (aAPCs) in the clinic as
cancer immunotherapeutics are hindered by the need of identifying immunogenic cancer …

The development of effective antitumor immune responses is normally constrained by low-
avidity, tumor-specific CTLs that are unable to eradicate the tumor. Strategies to rescue …

CD4+ T cells play a central role in protective immunity. In a mouse tumor model, we
previously found that tumor growth elicits natural CD4+ T-cell responses, but impedes …

Cell-free artificial antigen-presenting cells (aAPCs) were generated by coupling H-
2Kb/TRP2 tetramers together with anti-CD28 and anti-4-1BB antibodies onto cell-sized latex …

Active anti-cancer immune responses depend on efficient presentation of tumor antigens
and co-stimulatory signals by antigen-presenting cells (APCs). Therapy with autologous …

Accumulating evidence support an important role for endogenous bystander dendritic cells
(DCs) in the efficiency of autologous patient-derived DC-vaccines, as bystander DCs take up …

Antigen-presenting cells expand antigen-specific T cells ex vivo and in vivo for tumor
immunotherapy, but are time-consuming to generate and, as live cells, raise biosafety …