Immunogenic tumors grow progressively even when heavily infiltrated by CD8+ T cells. We
investigated how to rescue CD8+ T-cell function in long-established immunogenic …

The in vitro generation of cytotoxic T lymphocytes (CTLs) for anticancer immunotherapy is a
promising approach to take patient-specific therapy from the bench to the bedside. Two …

Vaccines have been hailed as one of the most remarkable medical advancements in human
history, and their potential for treating cancer by generating or expanding anti-tumor T cells …

Both prophylactic and therapeutic vaccines targeting a wide variety of cancers are being
developed. Because of the potency of cell-mediated immunity, many vaccine strategies are …

Both innate and adaptive immunity are crucial for cancer immunosurveillance, but precise
therapeutic equations to restore immunosurveillance in patients with cancer patients have …

Evaluation of: Aarntzen EH, De Vries IJ, Lesterhuis WJ et al. Targeting CD4+ T-helper cells
improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer …

Building on significant advances in basic tumor immunology over the past decade, current
translational efforts to develop novel antitumor T cell the rapeutics continue to accelerate …

Dendritic cell (DC)-based vaccines against cancer have been extensively developed over
the past two decades. Typically DC-based cancer immunotherapy entails loading patient …

Substantial evidence indicates that immunotherapy is a feasible and effective approach for
the treatment of numerous types of cancer. Among various immunotherapy options, peptide …

Cancer stem cells (CSCs) represent a small subset of tumor cells which have the ability to
self-renew and generate the diverse cells that comprise the tumor bulk. They are …