[HTML][HTML] FKBP10 regulates protein translation to sustain lung cancer growth

G Ramadori, RM Ioris, Z Villanyi, R Firnkes… - Cell reports, 2020 - cell.com
Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are
selectively expressed by, and relevant for, cancer cells is of paramount medical importance …

[HTML][HTML] FKBP3 promotes proliferation of non-small cell lung cancer cells through regulating Sp1/HDAC2/p27

W Zhu, Z Li, L Xiong, X Yu, X Chen, Q Lin - Theranostics, 2017 - ncbi.nlm.nih.gov
FKBP3 is a member of FK506-binding proteins (FKBPs). Little is known about the expression
and functional role (s) of FKBP3 in non-small cell lung cancer (NSCLC). In the present study …

[HTML][HTML] Penetrating exploration of prognostic correlations of the FKBP gene family with lung adenocarcinoma

CC Wang, WJ Shen, G Anuraga, YH Hsieh… - Journal of Personalized …, 2022 - mdpi.com
The complexity of lung adenocarcinoma (LUAD), the development of which involves many
interacting biological processes, makes it difficult to find therapeutic biomarkers for …

FKBP4 accelerates malignant progression of non‐small‐cell lung cancer by activating the Akt/mTOR signaling pathway

W Meng, J Meng, H Jiang, X Feng… - Analytical Cellular …, 2020 - Wiley Online Library
Objective. To study the expression, biological function, and mechanism of FKBP4 in non‐
small‐cell lung cancer (NSCLC). Methods. First of all, the expression of FKBP4 in NSCLC …

[HTML][HTML] FKBP51 induces p53‑dependent apoptosis and enhances drug sensitivity of human non‑small‑cell lung cancer cells

Y Chen, Z Liu, Y Wang, J Zhuang… - Experimental and …, 2020 - spandidos-publications.com
Lung cancer is one of the most prevalent cancer types worldwide, and non‑small‑cell lung
cancer (NSCLC) accounts for~ 85% of all lung cancer cases. Despite the notable …

[HTML][HTML] Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance

Y Fu, J Chen, X Ma, W Chang, X Zhang, Y Liu… - International Journal of …, 2023 - mdpi.com
FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in
cancer development, although its prognostic function remains controversial. In this study, we …

[HTML][HTML] FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis

HQ Cai, MJ Zhang, ZJ Cheng, J Yu, Q Yuan… - Journal of biomedical …, 2021 - Springer
Background Although the availability of therapeutic options including temozolomide,
radiotherapy and some target agents following neurosurgery, the prognosis of glioma …

[HTML][HTML] FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer

J Hou, L Wang - PloS one, 2012 - journals.plos.org
We have recently shown that the immunophilin FKBP5 (also known as FKBP51) is a
scaffolding protein that can enhance PHLPP-AKT interaction and facilitate PHLPP-mediated …

[HTML][HTML] FBXO22 mediates polyubiquitination and inactivation of LKB1 to promote lung cancer cell growth

XN Zhu, P He, L Zhang, S Yang, HL Zhang, D Zhu… - Cell death & …, 2019 - nature.com
Abstract Liver kinase B1 (LKB1) regulates both cell growth and energy metabolism.
Inactivated mutations of LKB1, observed in 20–30% of nonsmall cell lung cancers (NSCLC) …

Pleiotropic roles in cancer biology for multifaceted proteins FKBPs

S Romano, A D'Angelillo, MF Romano - Biochimica et Biophysica Acta …, 2015 - Elsevier
Background FK506 binding proteins (FKBP) are multifunctional proteins highly conserved
across the species and abundantly expressed in the cell. In addition to a well-established …