Immunosenescence, inflammaging, and frailty: role of myeloid cells in age-related diseases

A Bleve, F Motta, B Durante, C Pandolfo… - Clinical reviews in …, 2022 - Springer
The immune system is the central regulator of tissue homeostasis, ensuring tissue
regeneration and protection against both pathogens and the neoformation of cancer cells. Its …

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

MT Ventura, M Casciaro, S Gangemi… - Clinical and Molecular …, 2017 - Springer
Background The immunosenescence is a relatively recent chapter, correlated with the linear
extension of the average life began in the nineteenth century and still in progress. The most …

Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention

A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …

Aging and the immune system: An overview

AAS Akha - Journal of immunological methods, 2018 - Elsevier
The world is witnessing a rapid demographic shift towards an older population, a trend with
major medical, social, economic and political implications. Aging is a multifaceted process …

[HTML][HTML] Hallmarks of aging and immunosenescence: connecting the dots

LP Rodrigues, VR Teixeira, T Alencar-Silva… - Cytokine & growth factor …, 2021 - Elsevier
Aging is a natural physiological process that features various and variable challenges,
associated with loss of homeostasis within the organism, often leading to negative …

From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

M Bulati, C Caruso, G Colonna-Romano - Ageing research reviews, 2017 - Elsevier
Ageing is a complex process characterized by a general decline in physiological functions
with increasing morbidity and mortality. The most important aspect of ageing is the chronic …

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

V Bueno, OA Sant'Anna, JM Lord - Age, 2014 - Springer
Infections, cancer and autoimmune diseases occur more frequently in the elderly, and
although many factors contribute to this, the age-related remodelling of the immune system …

Interconnections between inflammageing and immunosenescence during ageing

T Teissier, E Boulanger, LS Cox - Cells, 2022 - mdpi.com
Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Inflamm-aging: autoimmunity, and the immune-risk phenotype

E Boren, ME Gershwin - Autoimmunity reviews, 2004 - Elsevier
Aging of the immune system, or immunosenescence, is a complex subject best defined as a
decline in cell-mediated immunity, particularly with respect to T cell function. Paradoxically …

Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?

T Fulop, A Larbi, G Dupuis, A Le Page… - Frontiers in …, 2018 - frontiersin.org
The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …