Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

The function of the immune system is known to decline in the elderly. The present
communication will show that, similar to the situation in children, it is necessary to …

Age-related alterations of the immune system represent a complex, multifactorial, and poorly
understood series of events that affect both the innate and adaptive compartments …

Immune system alterations during ageing are complex and pleiotropic, suggestive of
remodelling or altered regulation, rather than simple immune deficiency. The most dramatic …

Aging is one of the principal unsolved enigmas remaining in cellular and molecular biology.
This challenge, and the potential for discoveries that may delay the onset or lessen the …

The world is witnessing a rapid demographic shift towards an older population, a trend with
major medical, social, economic and political implications. Aging is a multifaceted process …

Publisher Summary This chapter discusses the basis for age-dependent changes in immune
function. Aging converts a fit, mature adult into an increasingly infirm one. The mechanisms …

Immunosenescence is a term used to describe the age-related changes in the immune
system. Immunosenescence is associated with complex alterations and dysregulation of …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …