Channelopathies in Cav1.1, Cav1.3, and Cav1.4 voltage-gated L-type Ca2+ channels
J Striessnig, HJ Bolz, A Koschak - Pflügers Archiv-European Journal of …, 2010 - Springer
Voltage-gated Ca 2+ channels couple membrane depolarization to Ca 2+-dependent
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …
intracellular signaling events. This is achieved by mediating Ca 2+ ion influx or by direct …
L-type Ca2+ channels in Ca2+ channelopathies
J Striessnig, JC Hoda, A Koschak, F Zaghetto… - Biochemical and …, 2004 - Elsevier
Voltage-gated L-type Ca2+ channels (LTCCs) mediate depolarization-induced Ca2+ entry
in electrically excitable cells, including muscle cells, neurons, and endocrine and sensory …
in electrically excitable cells, including muscle cells, neurons, and endocrine and sensory …
Hallmarks of the channelopathies associated with L-type calcium channels: A focus on the Timothy mutations in Cav1. 2 channels
I Bidaud, P Lory - Biochimie, 2011 - Elsevier
Within the voltage-gated calcium channels (Cav channels) family, there are four genes
coding for the L-type Cav channels (Cav1). The Cav1 channels underly many important …
coding for the L-type Cav channels (Cav1). The Cav1 channels underly many important …
[HTML][HTML] Voltage-gated calcium channels in genetic diseases
Voltage-gated calcium channels (VGCCs) mediate calcium entry into excitable cells in
response to membrane depolarization. During the past decade, our understanding of the …
response to membrane depolarization. During the past decade, our understanding of the …
CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency
Mutations of human Ca V 1.2 channel gene were identified only recently. The gain-of-
function mutations were found at two mutually exclusive exons in patients with Timothy …
function mutations were found at two mutually exclusive exons in patients with Timothy …
The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function
SM Berger, D Bartsch - Cell and tissue research, 2014 - Springer
The use of specific activators and inhibitors that penetrate the central nervous system has
suggested an essential functional role of L-type calcium channels (LTCC) in several …
suggested an essential functional role of L-type calcium channels (LTCC) in several …
Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels
J Platzer, J Engel, A Schrott-Fischer, K Stephan… - Cell, 2000 - cell.com
Voltage-gated L-type Ca 2+ channels (LTCCs) containing a pore-forming α1D subunit (D-
LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to …
LTCCs) are expressed in neurons and neuroendocrine cells. Their relative contribution to …
L‐type Ca2+ channels in heart and brain
J Striessnig, A Pinggera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …
C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1. 3 L-type Ca2+ channels
A Lieb, N Ortner, J Striessnig - Biophysical journal, 2014 - cell.com
Activity of voltage-gated Ca v 1.3 L-type Ca 2+ channels is required for proper hearing as
well as sinoatrial node and brain function. This critically depends on their negative activation …
well as sinoatrial node and brain function. This critically depends on their negative activation …
Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia
Q Zhang, J Chen, Y Qin, J Wang, L Zhou - Channels, 2018 - Taylor & Francis
The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …