Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state
A Kashiwagi, K Shinozaki, Y Nishio, T Okamura… - Diabetes research and …, 1999 - Elsevier
Impairment of nitric oxide-dependent vascular relaxation is a characteristic feature of the
insulin-resistant state. To understand those mechanisms, we examined imbalance of …
insulin-resistant state. To understand those mechanisms, we examined imbalance of …
Effect of endothelium-specific insulin resistance on endothelial function in vivo
ER Duncan, PA Crossey, S Walker, N Anilkumar… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Insulin resistance is an independent risk factor for the development of
cardiovascular atherosclerosis. A key step in the development of atherosclerosis is …
cardiovascular atherosclerosis. A key step in the development of atherosclerosis is …
[PDF][PDF] Free radicals, diabetes and endothelial dysfunction
U Bayraktutan - Diabetes Obesity and Metabolism, 2002 - eprints.nottingham.ac.uk
Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is
associated with several vascular complications. Although insulin treatment, oral …
associated with several vascular complications. Although insulin treatment, oral …
Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species
ER Duncan, SJ Walker, VA Ezzat… - American Journal …, 2007 - journals.physiology.org
Insulin resistance is well established as an independent risk factor for the development of
type 2 diabetes and cardiovascular atherosclerosis. Most studies have examined …
type 2 diabetes and cardiovascular atherosclerosis. Most studies have examined …
[HTML][HTML] Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function
Insulin resistance promotes vascular endothelial dysfunction and subsequent development
of cardiovascular disease. Previously we found that skeletal muscle arteriolar flow-induced …
of cardiovascular disease. Previously we found that skeletal muscle arteriolar flow-induced …
Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress
To test the deterioration of endothelial function during the progression of diabetes, shear
stress-induced dilation (SSID; 10, 20, and 40 dyn/cm2) was determined in isolated …
stress-induced dilation (SSID; 10, 20, and 40 dyn/cm2) was determined in isolated …
Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo
DW Laight, KM Desai, EE Änggård… - European journal of …, 2000 - Elsevier
We have recently made the novel observation that a pro-oxidant challenge with
hydroquinone in combination with buthionine sulfoximine (each at 50 mg/kg ip daily for 7 …
hydroquinone in combination with buthionine sulfoximine (each at 50 mg/kg ip daily for 7 …
Diabetes mellitus, oxidative stress and endothelial dysfunction
K Sydow, T Münzel - International Congress Series, 2003 - Elsevier
Hyperglycemia is the major causal factor in the development of endothelial dysfunction in
patients with diabetes mellitus. There is experimental and clinical evidence linking …
patients with diabetes mellitus. There is experimental and clinical evidence linking …
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD (P) H oxidase and endothelial nitric oxide synthase
TJ Guzik, S Mussa, D Gastaldi, J Sadowski… - Circulation, 2002 - Am Heart Assoc
Background—Increased superoxide production contributes to reduced vascular nitric oxide
(NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We …
(NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We …
Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta.
K Shinozaki, A Kashiwagi, Y Nishio, T Okamura… - Diabetes, 1999 - Am Diabetes Assoc
To investigate underlying mechanisms responsible for the impaired nitric oxide (NO)-
dependent vascular relaxation in the insulin-resistant state, we examined production of both …
dependent vascular relaxation in the insulin-resistant state, we examined production of both …
相关搜索
- oxidative stress endothelial dysfunction
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- zucker rat endothelial dysfunction
- progression of diabetes endothelial dysfunction
- oxygen species insulin resistance
- insulin resistant endothelial dysfunction
- diabetes mellitus endothelial dysfunction