Impairment of nitric oxide-dependent vascular relaxation is a characteristic feature of the
insulin-resistant state. To understand those mechanisms, we examined imbalance of …

OBJECTIVE—Insulin resistance is an independent risk factor for the development of
cardiovascular atherosclerosis. A key step in the development of atherosclerosis is …

Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is
associated with several vascular complications. Although insulin treatment, oral …

Insulin resistance is well established as an independent risk factor for the development of
type 2 diabetes and cardiovascular atherosclerosis. Most studies have examined …

Insulin resistance promotes vascular endothelial dysfunction and subsequent development
of cardiovascular disease. Previously we found that skeletal muscle arteriolar flow-induced …

To test the deterioration of endothelial function during the progression of diabetes, shear
stress-induced dilation (SSID; 10, 20, and 40 dyn/cm2) was determined in isolated …

We have recently made the novel observation that a pro-oxidant challenge with
hydroquinone in combination with buthionine sulfoximine (each at 50 mg/kg ip daily for 7 …

Hyperglycemia is the major causal factor in the development of endothelial dysfunction in
patients with diabetes mellitus. There is experimental and clinical evidence linking …

Background—Increased superoxide production contributes to reduced vascular nitric oxide
(NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We …

To investigate underlying mechanisms responsible for the impaired nitric oxide (NO)-
dependent vascular relaxation in the insulin-resistant state, we examined production of both …