Myocardial ischemia is the leading cause of death in both men and women; however, very
little information exists regarding the effect of testosterone on the response of myocardium to …

Chronic endogenous testosterone exposure adversely affects proinflammatory and
proapoptotic signaling after ischemia/reperfusion; however, it remains unknown whether a …

Cardiac rupture can be fatal after myocardial infarction (MI). Experiments in animals
revealed gender differences in rupture rate; however, patient data are controversial. We …

[Frontiers in Bioscience 10, 1835-1867, May 1, 2005] 1835 INTRACELLULAR SIGNALING
MECHANISMS OF SEX HORMONES IN ACUTE MYOCARDIAL Page 1 [Frontiers in …

This study investigated the impact of testosterone on myocardial ischemia-reperfusion injury
and corresponding intracellular calcium ([Ca2+] i) metabolism. Nonorchiectomized mature …

We tested the hypothesis that chronic testosterone treatment would promote a
cardioprotective phenotype against ischemia/reperfusion (I/R) injury. For this study, 3-month …

The myocardium generates inflammatory mediators during ischemia-reperfusion (I/R), and
these mediators contribute to cardiac functional depression and apoptosis. The great …

BACKGROUND: Lower levels of myocardial Akt activity in males are associated with a
higher incidence of heart failure and worsened cardiac function after ischemia/reperfusion …

Important sex differences in the onset and characteristics of cardiovascular disease are
evident, yet the mechanistic details remain unresolved. Men are more susceptible to …

Testosterone is an anabolic steroid hormone, which is the major circulating androgen
hormone in males. Testosterone levels decreasing below the normal physiological levels …