Men are at greater risk for renal injury and dysfunction after acute ischemia-reperfusion (I/R)
than are women. Studies in animals suggest that the reason for the sex difference in renal …

Experimental studies indicate that ischemia/reperfusion (I/R) causes remote organ injury
although the molecular mechanism has not been clearly defined. In this report, the role of …

The conventional view is that estrogen confers female cardioprotection. Estrogen synthesis
depends on androgen availability, with aromatase regulating conversion of testosterone to …

Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …

The study was designed to investigate the effect of progesterone and its gender based
variation on myocardial ischemia/reperfusion (I/R) injury in rats. Adult Sprague Dawley rats …

Previous studies have reported the sex differences in heart susceptibility to
ischemia/reperfusion (I/R) injury, but the mechanisms are not understood. The present study …

The molecular and pharmacological manipulation of the endogenous redox system is a
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …

BACKGROUND: After ischemia/reperfusion (I/R) injury, female hearts demonstrate improved
functional recovery compared with male, which suggests a protective role for estrogen …

To compare ischemia-reperfusion injury in males versus females under hypercontractile
conditions, perfused hearts from 129J mice pretreated with 3 mmol/l Ca2+ or 10− 8 mol/l …

The purpose of this study was to test whether the susceptibility of the heart to
ischemia/reperfusion injury is modulated by the chronic estrogen status, ie, increased with …