Protective role of testosterone in ischemia-reperfusion-induced acute kidney injury
A Soljancic, AL Ruiz… - American Journal …, 2013 - journals.physiology.org
Men are at greater risk for renal injury and dysfunction after acute ischemia-reperfusion (I/R)
than are women. Studies in animals suggest that the reason for the sex difference in renal …
than are women. Studies in animals suggest that the reason for the sex difference in renal …
Effects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in rats
Experimental studies indicate that ischemia/reperfusion (I/R) causes remote organ injury
although the molecular mechanism has not been clearly defined. In this report, the role of …
although the molecular mechanism has not been clearly defined. In this report, the role of …
Aromatase deficiency confers paradoxical postischemic cardioprotection
The conventional view is that estrogen confers female cardioprotection. Estrogen synthesis
depends on androgen availability, with aromatase regulating conversion of testosterone to …
depends on androgen availability, with aromatase regulating conversion of testosterone to …
Estrogen receptor β mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia
M Wang, Y Wang, B Weil… - American Journal …, 2009 - journals.physiology.org
Females have a lower incidence of heart failure and improved survival after myocardial
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …
ischemia-reperfusion (I/R) compared with males. Although estrogen-suppressed …
Gender specific effect of progesterone on myocardial ischemia/reperfusion injury in rats
VV Dhote, R Balaraman - Life Sciences, 2007 - Elsevier
The study was designed to investigate the effect of progesterone and its gender based
variation on myocardial ischemia/reperfusion (I/R) injury in rats. Adult Sprague Dawley rats …
variation on myocardial ischemia/reperfusion (I/R) injury in rats. Adult Sprague Dawley rats …
Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling
Previous studies have reported the sex differences in heart susceptibility to
ischemia/reperfusion (I/R) injury, but the mechanisms are not understood. The present study …
ischemia/reperfusion (I/R) injury, but the mechanisms are not understood. The present study …
[HTML][HTML] Uncovering sex-specific mechanisms of action of testosterone and redox balance
D Cruz-Topete, P Dominic, KY Stokes - Redox Biology, 2020 - Elsevier
The molecular and pharmacological manipulation of the endogenous redox system is a
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …
Acute postischemic treatment with estrogen receptor-α agonist or estrogen receptor-β agonist improves myocardial recovery
ND Vornehm, M Wang, A Abarbanell, J Herrmann… - Surgery, 2009 - Elsevier
BACKGROUND: After ischemia/reperfusion (I/R) injury, female hearts demonstrate improved
functional recovery compared with male, which suggests a protective role for estrogen …
functional recovery compared with male, which suggests a protective role for estrogen …
Ca2+ loading and adrenergic stimulation reveal male/female differences in susceptibility to ischemia-reperfusion injury
HR Cross, E Murphy… - American Journal of …, 2002 - journals.physiology.org
To compare ischemia-reperfusion injury in males versus females under hypercontractile
conditions, perfused hearts from 129J mice pretreated with 3 mmol/l Ca2+ or 10− 8 mol/l …
conditions, perfused hearts from 129J mice pretreated with 3 mmol/l Ca2+ or 10− 8 mol/l …
Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status
S Beer, M Reincke, M Kral, SZ Lie… - Journal of …, 2002 - journals.lww.com
The purpose of this study was to test whether the susceptibility of the heart to
ischemia/reperfusion injury is modulated by the chronic estrogen status, ie, increased with …
ischemia/reperfusion injury is modulated by the chronic estrogen status, ie, increased with …