Over the last 5 years, disorders of nonmotile cilia have come of age and their study has
contributed immeasurably to our understanding of cell biology and human genetics. This …

Motile cilia have long been known to play a role in processes such as cell locomotion and
fluid movement whereas the functions of primary cilia have remained obscure until recent …

Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …

Primary cilia have a broad tissue distribution and are present on most cell types in the
human body. Until recently, they were considered to be redundant organelles, but progress …

Ubiquitous in nature, cilia and flagella comprise nearly identical structures with similar
functions. The most obvious example of the latter is motility: driving movement of the …

Ciliopathies comprise a group of complex disorders, with involvement of the majority of
organs and systems. In total,> 180 causal genes have been identified and, in addition to …

Genetic diseases known as ciliopathies have recently entered the limelight, placing new
importance on a previously mysterious organelle: the primary cilium. Mutations affecting the …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Research of cilia has gained significant momentum in the last 15 years, as an increasing
number of human genetic diseases were found to be caused by disruption of a protein that …

The role of mammalian cilia in cell signalling was first identified in embryonic development
and subsequent analysis has revealed roles in multiple signalling pathways. We now …