Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Background: Although intermittent bolus dosing is currently the standard of practice for many
antimicrobial agents, beta-lactams exhibit time-dependent bacterial killing. Maximizing the …

The treatment of infections in critically ill obese and morbidly obese patients is challenging
because of the combined physiological changes that result from obesity and critical illness …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

This study examined the effect of various levels of renal impairment on the probability of
achieving free drug concentrations that exceed the MIC for 50% of the dosing interval (50% f …

Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

Beta-lactams are regularly administered in intermittent short-term infusions. The percentage
of the dosing interval during which free drug concentrations exceed the MIC (fT> MIC) is the …

The pharmacodynamics of dosage regimens of piperacillin alone or in combination with
tazobactam against piperacillin-resistant or-susceptible bacteria were studied in an in vitro …

Purpose The aim of the study was to investigate the in vitro antiinfective effect of piperacillin-
tazobactam (PIP-TZB) combinations on Escherichia coli in simulations of free concentration …

Study Objective To evaluate the steady‐state pharmacokinetic and pharmacodynamic
parameters of piperacillin in morbidly obese, surgical intensive care patients. Design Open …