Piperacillin/tazobactam is a new combination of a broad-spectrum penicillin and a beta-
lactamase inhibitor. In studies in healthy volunteers, the pharmacokinetics of piperacillin …

The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …

Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …

The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics
of piperacillin and tazobactam administered by prolonged infusion in obese patients …

Because the sepsis-induced pharmacokinetic (PK) modifications need to be considered in
aminoglycoside dosing, the present study aimed to develop a population PK model for …

Purpose. It was the aim of the present study to investigate the in vitro antimicrobial effects of
the β-lactam antibiotic piperacillin on Escherichia coli using concentration-time profiles …

The treatment of sepsis remains a significant challenge and is the cause of high mortality
and morbidity. The pathophysiological alterations that are associated with sepsis can …

Objectives The objective of this study was to investigate the population pharmacokinetics
and pharmacodynamics of amoxicillin and clavulanic acid in critically ill patients. Methods In …

Study Objective. To compare conventional intermittent dosing regimens of piperacillin‐
tazobactam with prolonged and continuous infusions to determine the optimal dosing …

Purpose The purpose of this study is to review the rationale of prolonged (ie, extended or
continuous) infusion of piperacillin/tazobactam (PIP/TAZ) in critically ill patients and to …