Objective To explore the effects of renal function estimated by measured creatinine
clearance (Cl CR) on trough serum concentration (C min) of piperacillin given to critically ill …

In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics.
Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Background Recently, continuous administration of piperacillin-tazobactam has been
proposed as a valuable alternative to traditional intermittent administration especially in …

Critically ill patients with sepsis or septic shock are at an increased risk of death. Early and
aggressive interventions are essential for improving clinical outcomes. There are a number …

In order to eradicate an infecting organism, it is necessary to achieve or maintain
concentrations of an antibiotic in vivo that exceed the minimum inhibitory concentration …

Background and aims Temocillin, a 6α-methoxy-penicillin stable towards most β-lactamases
(including extended-spectrum β-lactamase), is presented as an alternative to carbapenems …

The pharmacodynamics and pharmacokinetics of ceftazidime administered by continuous
infusion and intermittent bolus over a 4-day period were compared. We conducted a …

This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU),
with an average age of 69 years, without neurologic disorder before initiation of a …