Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Enormous advances have been made in the last decade in understanding iron metabolism
and iron homeostasis at both the cellular and the systemic level. This includes the …

Humans possess elegant control mechanisms to maintain iron homeostasis by coordinately
regulating iron absorption, iron recycling, and mobilization of stored iron. Dietary iron …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Iron is a vital trace element for humans, as it plays a crucial role in oxygen transport,
oxidative metabolism, cellular proliferation, and many catalytic reactions. To be beneficial …

Iron is an essential trace element, but it is also toxic in excess, and thus mammals have
developed elegant mechanisms for keeping both cellular and whole-body iron …

Iron metabolism in man is a highly regulated process designed to provide iron for
erythropoiesis, mitochondrial energy production, electron transport, and cell proliferation …

The liver is the organ for iron storage and regulation; it senses circulating iron
concentrations in the body through the BMP‐SMAD pathway and regulates the iron intake …