Imaging mass spectrometry: fundamentals and applications to drug discovery

SS Rubakhin, JC Jurchen, EB Monroe, JV Sweedler - Drug discovery today, 2005 - Elsevier
Imaging mass spectrometry (IMS) encompasses a variety of techniques that enable the
chemical imaging of analytes, which range in size from atoms and small molecules to intact …

[图书][B] Imaging mass spectrometry: protocols for mass microscopy

M Setou - 2010 - books.google.com
Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS),
this book presents the protocols of IMS technology. As that technology expands, research …

A critical and concise review of mass spectrometry applied to imaging in drug discovery

RJA Goodwin, Z Takats… - … : Advancing the Science of …, 2020 - journals.sagepub.com
During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …

Mass spectrometry imaging in drug development

A Nilsson, RJA Goodwin, M Shariatgorji… - Analytical …, 2015 - ACS Publications
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

Mass spectrometry imaging for drug distribution studies

B Prideaux, M Stoeckli - Journal of proteomics, 2012 - Elsevier
Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

CB Lietz, E Gemperline, L Li - Advanced drug delivery reviews, 2013 - Elsevier
Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical
sciences. While quantitative whole-body autoradiography and microautoradiography are the …

Current state and future challenges of mass spectrometry imaging for clinical research

RD Addie, B Balluff, JVMG Bovée, H Morreau… - 2015 - ACS Publications
The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues,
without prior knowledge of their presence and in a label-free manner, has led to a rapid and …

Mass spectrometry imaging for drugs and metabolites

T Greer, R Sturm, L Li - Journal of proteomics, 2011 - Elsevier
Mass spectrometric imaging (MSI) is a powerful analytical technique that provides two-and
three-dimensional spatial maps of multiple compounds in a single experiment. This …

Imaging mass spectrometry: molecular microscopy for the new age of biology and medicine

RM Caprioli - Proteomics, 2016 - Wiley Online Library
Imaging mass spectrometry provides a powerful tool for monitoring and discovery of
molecular processes in the spatial domain in tissues for research and practical applications …

[HTML][HTML] Imaging mass spectrometry in drug development and toxicology

O Karlsson, J Hanrieder - Archives of toxicology, 2017 - Springer
During the last decades, imaging mass spectrometry has gained significant relevance in
biomedical research. Recent advances in imaging mass spectrometry have paved the way …