Adult stem cells play an essential role in mammalian organ maintenance and repair
throughout adulthood since they ensure that organs retain their ability to regenerate. The …

Satellite cells are unipotent stem cells involved in muscle regeneration. However, the
skeletal muscle microenvironment exerts a dominant influence over stem cell function. The …

Skeletal muscles in vertebrates have a phenomenal regenerative capacity. A muscle that
has been crushed can regenerate fully both structurally and functionally within a month …

Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-
renewing population of satellite cells has only recently been defined through genetic and …

The proper functioning of tissues and organs depends on their ability to self-renew and
repair. Some of the tissues, like epithelia, renew almost constantly while in the others this …

Developmental and regenerative mechanisms are directed by stem cell populations.
Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury …

Identification of human satellite cells that fulfill muscle stem cell criteria is an unmet need in
regenerative medicine. This hurdle limits understanding how closely muscle stem cell …

The goal of regenerative medicine is to restore form and function to damaged and aging
tissues. Adult stem cells, present in tissues such as skeletal muscle, comprise a reservoir of …

Muscle tissue represents an abundant, accessible, and replenishable source of adult stem
cells for cell-based tissue and genetic engineering. A population of cells isolated from …

Transplanting adult stem cells provides a stringent test for self-renewal and the assessment
of comparative engraftment in competitive transplant assays. Transplantation of satellite …