[HTML][HTML] Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond
50% of its normal diameter, is a common and potentially life-threatening vascular disease …
50% of its normal diameter, is a common and potentially life-threatening vascular disease …
[HTML][HTML] Dysregulations of key regulators of angiogenesis and inflammation in abdominal aortic aneurysm
D Zalewski, P Chmiel, P Kołodziej, G Borowski… - International Journal of …, 2023 - mdpi.com
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm—brief report
Objective: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …
characterized by smooth muscle cell depletion, ECM (extracellular matrix) degradation, and …
Endothelium as a potential target for treatment of abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) was previously ascribed to weaken defective medial
arterial/adventitial layers, for example, smooth muscle/fibroblast cells. Therefore, besides …
arterial/adventitial layers, for example, smooth muscle/fibroblast cells. Therefore, besides …
[HTML][HTML] Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta
Aims The artery contains numerous cell types which contribute to multiple vascular
diseases. However, the heterogeneity and cellular responses of these vascular cells during …
diseases. However, the heterogeneity and cellular responses of these vascular cells during …
[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm
R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …
[HTML][HTML] Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm
Background An animal model commonly used to investigate pathways and potential
therapeutic interventions relevant to abdominal aortic aneurysm (AAA) involves …
therapeutic interventions relevant to abdominal aortic aneurysm (AAA) involves …
Cellular signaling in abdominal aortic aneurysm
Z Li, W Kong - Cellular signalling, 2020 - Elsevier
Abdominal aortic aneurysms (AAAs) are highly lethal cardiovascular diseases without
effective medications. However, the molecular and signaling mechanisms remain unclear. A …
effective medications. However, the molecular and signaling mechanisms remain unclear. A …
Understanding the pathogenesis of abdominal aortic aneurysms
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …
the aortic wall continues to weaken and becomes unable to withstand the forces of the …