Simple Summary Despite their potential and promising anti-tumor efficacy, previously
developed cancer vaccines targeting different tumor-associated antigens for colorectal …

Renal cell carcinoma (RCC) is the deadliest form of urological cancer and is projected to be
the fourth most common neoplasm in the USA in males by 2040. In addition to the current …

Cancer immunotherapy, including vaccination, is considered a major scientific and medical
breakthrough. However, cancer immunotherapy does not result in durable objective …

Infiltration of immunosuppressive cells in the tumor microenvironment (TME) induced
colorectal cancer (CRC) progression and its resistance to immunotherapy. Identification of …

About 85% of patients with colorectal cancer (CRC) have the non-microsatellite instability-
high (non-MSI-H) subtype, and many cannot benefit from immune checkpoint blockade. A …

It is unknown as to how liver metastases are correlated with host immune status in colorectal
cancer. In this study, we found that IL6, a proinflammatory cytokine produced in tumor …

Simple Summary Peptide-based cancer vaccines require adjuvants to increase their
immunogenicity to mount an antigen-specific reliable immune response. We have previously …

Progressive tumor growth is associated with deficits in the immunity generated against tumor
antigens. Vaccines targeting tumor neoepitopes have the potential to address qualitative …

Autologous cancer vaccines (ACVs) are a desirable approach for personalized medicine,
but the efficiency of ACVs remains unsatisfactory due to their low immunogenicity. This study …

Over the last few decades, major efforts in cancer research and treatment have intensified.
Apart from standard chemotherapy approaches, immunotherapy has gained substantial …