Alternative pre–messenger RNA splicing influences development, physiology and disease,
but its regulation in humans is not well understood, partially because of the limited scale at …

Alternative splicing has a crucial role in the generation of biological complexity, and its
misregulation is often involved in human disease. Here we describe the assembly of a …

Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development,
physiology, and disease, and more than half of human genes are alternatively spliced. To …

To better decipher the functional impact of alternative splicing, we classified alternative
splicing events in 10 818 pairs of human and mouse genes based on conservation at …

Alternative splicing (AS) is a fundamental step in eukaryotic mRNA biogenesis. Here, we
develop an efficient and reproducible pipeline for the discovery of genetic variants that affect …

Alternative splicing is a major contributor to genomic complexity, disease, and development.
Previous studies have captured some of the characteristics that distinguish alternative …

Alternative splicing is a major cellular mechanism in metazoans for generating proteomic
diversity. A large proportion of protein-coding genes in multicellular organisms undergo …

Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a
single primary transcript, significantly expanding the information content and regulatory …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that
splicing together of different combinations of splice sites–alternative splicing–allows …