Background When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies
functional esophageal disorders into functional heartburn (FH, with negative reflux‐symptom …

BACKGROUND Functional heartburn (FH) patients have a profound impact on the response
to anti-reflux therapy of the nonerosive reflux disease (NERD) group as compared to the …

Background Bowel symptoms have been associated with non‐erosive reflux disease
(NERD). However, their role in functional heartburn (FH) has not been established. Aims To …

Background Little is known about possible underlying psychological abnormalities and
physiology of reflux hypersensitivity (RH) as defined in the recent Rome IV classification. We …

Background The pathogenesis of gastro‐oesophageal reflux disease (GERD) is complex
and multifactorial. The oesophageal hypervigilance and anxiety scale (EHAS) is a novel …

INTRODUCTION: Functional heartburn is defined by Rome III criteria as an endoscopy-
negative condition with normal oesophageal acid exposure time, negative symptom …

The better ability to interpret impedance-pH tracings together with earlier data on the
different prevalence of microscopic esophagitis in RH and FH patients, and recent studies …

Functional heartburn (FH) is defined as a functional esophageal disorder characterized by
symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In …

Background & Aims Reflux hypersensitivity (RH), a functional esophageal disorder, is
detected in 14%–20% of patients who present with typical esophageal symptoms. As many …

Methods Patients having weekly heartburn or acid regurgitation were classified into four
pathophysiological subgroups according to endoscopy and pH monitoring: reflux …