INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of …

Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …

Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

Abstract The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human
Cell Atlas, aims to create a comprehensive reference map of cells during development. This …

Background Organogenesis is crucial for proper organ formation during mammalian
embryonic development. However, the similarities and shared features between different …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …