p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
K Kurokawa, T Tanaka, J Kato - Oncogene, 1999 - nature.com
Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
p14ARF induces G2 cell cycle arrest in p53-and p21-deficient cells by down-regulating p34cdc2 kinase activity
G Normand, PG Hemmati, B Verdoodt… - Journal of Biological …, 2005 - ASBMB
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis
PG Hemmati, B Gillissen, C von Haefen, J Wendt… - Oncogene, 2002 - nature.com
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53
The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
ARF regulates the stability of p16 protein via REGγ-dependent proteasome degradation
T Kobayashi, J Wang, H Al-Ahmadie… - Molecular Cancer …, 2013 - AACR
The cell-cycle regulatory gene INK4A-ARF (CDKN2A) has two alternative transcripts that
produce entirely different proteins, namely p14ARF and p16, which have complementary …
produce entirely different proteins, namely p14ARF and p16, which have complementary …
Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2
PA Clark, S Llanos, G Peters - Oncogene, 2002 - nature.com
The small basic protein p14 ARF, encoded by one of the alternative transcripts from the
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …