Theta-phase closed-loop stimulation induces motor paradoxical responses in the rat model of Parkinson disease

I Cordon, MJ Nicolás, S Arrieta, M Alegre, J Artieda… - Brain stimulation, 2018 - Elsevier
Background High-frequency deep brain stimulation (DBS) has become a widespread
therapy used in the treatment of Parkinson's Disease (PD) and other diseases. Although it …

Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease

DT Brocker, BD Swan, DA Turner, RE Gross… - Experimental …, 2013 - Elsevier
High frequency deep brain stimulation is an effective therapy for motor symptoms in
Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular …

Irregular high frequency patterns decrease the effectiveness of deep brain stimulation in a rat model of Parkinson's disease

RQ So, GC McConnell, JD Hilliard… - 2011 5th International …, 2011 - ieeexplore.ieee.org
Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease, but its
mechanisms are still unclear. To test the hypothesis that DBS alleviates motor symptoms by …

Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats

CS Oza, DT Brocker, CE Behrend… - Journal of …, 2018 - journals.physiology.org
Deep brain stimulation (DBS) is an effective therapy for movement disorders, including
Parkinson's disease (PD), although the mechanisms of action remain unclear. Abnormal …

Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling

CC Mcintyre, NV Thakor - Critical Reviews™ in Biomedical …, 2002 - dl.begellhouse.com
High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an
effective clinical technique for the treatment of several medically refractory movement …

Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation

GC McConnell, RQ So, WM Grill - Journal of …, 2016 - journals.physiology.org
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the
motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS …

Deep brain stimulation rectifies the noisy cortex and irresponsive subthalamus to improve parkinsonian locomotor activities

LHN Lee, CS Huang, RW Wang, HJ Lai… - npj Parkinson's …, 2022 - nature.com
The success of deep brain stimulation (DBS) therapy indicates that Parkinson's disease is a
brain rhythm disorder. However, the manifestations of the erroneous rhythms corrected by …

Closed-loop deep brain stimulation is superior in ameliorating parkinsonism

B Rosin, M Slovik, R Mitelman, M Rivlin-Etzion… - Neuron, 2011 - cell.com
Continuous high-frequency deep brain stimulation (DBS) is a widely used therapy for
advanced Parkinson's disease (PD) management. However, the mechanisms underlying …

Cortical effects of deep brain stimulation: implications for pathogenesis and treatment of Parkinson disease

Q Li, ZM Qian, GW Arbuthnott, Y Ke, WH Yung - JAMA neurology, 2014 - jamanetwork.com
High-frequency electrical stimulation that targets the subthalamic nucleus has proved to be
beneficial in alleviating the motor symptoms in many patients with Parkinson disease. The …

Closed-loop deep brain stimulation effects on parkinsonian motor symptoms in a non-human primate–is beta enough?

LA Johnson, SD Nebeck, A Muralidharan, MD Johnson… - Brain stimulation, 2016 - Elsevier
Background Incorporating feedback controls based on real-time measures of pathological
brain activity may improve deep brain stimulation (DBS) approaches for the treatment of …