Primary immunodeficiency diseases are inherited defects of the innate or adaptive arms of
the immune system that lead to an increase in the incidence, frequency, or severity of …

The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …

Highlights•Cell-intrinsic constitutive activation of type I interferon (IFN) can cause
autoinflammation.•Autoimmunity requires additional cell-extrinsic cues by the adaptive …

Severe mycobacterial disease is mostly confined to patients who are immunocompromized
either by acquired or inherited causes. One such genetic disorder is Mendelian …

IL-1R1 deficiency in mice causes severe susceptibility to Mycobacterium tuberculosis. Mice
and macrophage cultures lacking IL-1R1 display increased bacterial growth, suggesting that …

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of IFN-
γ immunity. Affected patients are highly and selectively susceptible to weakly virulent …

Abstract Interferon-γ receptor 2 (IFN-γR2) deficiency is a rare primary immunodeficiency
characterized by predisposition to infections with weakly virulent mycobacteria, such as …

Gamma interferon (IFNγ) was discovered in 1965 as an antiviral activity in white blood cell
cultures stimulated with the lymphocyte mitogen phytohemagglutinin (1). At that time, IFNγ …

Interferons (IFNs) are cytokines released by host cells in response to the presence of
pathogens or tumor cells. The aim of this review was to present the previously known and …

Purpose Mendelian suceptibility to mycobacterial disease (MSMD) is a rare primary
immunodeficiency predisposing to severe disease caused by mycobacteria and other …