BACKGROUND/OBJECTIVE: The IL-12–IFN-γ axis is critical for immune defense against
mycobacterial infections. Inherited mutations that affect normal activation of this self …

Mycobacterium tuberculosis is a highly successful human pathogen. A major component of
this success is the pathogen's ability to avoid eradication by the innate and adaptive immune …

Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from
these diseases would benefit not just from new medicines and vaccines but also from a …

The immune response upon infection with the pathogen Mycobacterium tuberculosis is
poorly understood, hampering the discovery of new treatments and the improvements in …

Immunity to Mycobacterium tuberculosis in humans and in mice requires interferon gamma
(IFN-γ). Whereas IFN-γ has been studied extensively for its effects on macrophages in …

Mycobacterial infections are critically controlled by interferon-γ (IFN-γ) and the cellular
responses it elaborates, as shown by patients with mutations in the IFN-γ receptor ligand …

Mendelian susceptibility to mycobacterial disease is a rare primary immunodeficiency
characterized by severe infections caused by weakly virulent mycobacteria. Biallelic null …

Loss of CD4 T cells is the hallmark of HIV infection. However, type I IFN-producing
plasmacytoid dendritic cells may also be lost. This results in susceptibility to an opportunistic …

Mycobacterial infections cause enormous morbidity and mortality worldwide, but the critical
aspects of the host response to them are still poorly understood. Over the past few years …

Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM) remain the
leading causes of lung disease and mortality worldwide. Interferon-gamma (IFN-γ) and its …