IFN-gamma is critical in the immune response to mycobacterial infections, and deficits in IFN-
gamma production and response have been associated with disseminated nontuberculous …

In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis
(Mtb), requires IFN-γ. Although the adaptive immune response results in production of …

The type I and II interferons (IFNs) play important roles in regulating immune responses
during viral and bacterial infections and in the context of autoimmune and neoplastic …

Mutations in the interferon (IFN)–γ receptor predispose to infection with bacille Calmette-
Guùrin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient …

New immunodeficiency syndromes that help us understand the I... : Current Opinion in
Pediatrics New immunodeficiency syndromes that help us understand the IFN-mediated …

The global burden of fungal diseases has been increasing, as a result of the expanding
number of susceptible individuals including people living with human immunodeficiency …

Interferon-γ (IFNγ) plays a major role during host defense against Mycobacterium
tuberculosis (Mtb). T cells produce IFNγ in response to IL-12 and IL-18 secreted from Mtb …

The role of Type I interferon (IFN) during pathogenic HIV and SIV infections remains unclear,
with conflicting observations suggesting protective versus immunopathological effects. We …

Type I and II interferons (IFNs αβ and γ) have opposing effects on immune resistance to
certain pathogenic bacteria. While IFNγ generally plays a protective role, IFNαβ exacerbates …

Primary immunodeficiency diseases consist of a group of more than 100 inherited
conditions, mostly monogenic, predisposing individuals to different sets of infections, allergy …