Multicellular tumor spheroids are attracting more attention as a physiologically relevant in
vitro tumor model for biomedical research. The size of spheroids is one of the critical …

Multicellular tumor spheroids (MCTSs) are in vitro solid tumor models with physiological
relevance. To achieve robust process control, a MCTS fabrication method that combines cell …

Spheroids are recognized for replicating the physiological microenvironment of tumours.
However, because of the lack of controllability of the spheroid size, the response to …

Tumor spheroids are increasingly recognized as an important in vitro model for the behavior
of tumor cells in three dimensions. More physiologically relevant than conventional adherent …

Tumor spheroids are three-dimensional clusters of cancer cells that exhibit characteristics of
poorly perfused tumors and hence present a relevant model for testing the efficacy of anti …

Multi-cellular tumor spheroids (MCTSs) have been established as a 3D physiologically
relevant tumor model for drug testing in cancer research. However, it is difficult to control the …

This paper presents a spheroid chip in which three-dimensional (3D) tumor spheroids are
not only formed by gravity-driven cell aggregation but also cultured at the perfusion rates …

Abstract Three-dimensional (3D) cell culture models have been extensively utilized in
various mechanistic studies as well as for drug development studies as superior in vitro …

Cancer cell spheroids present a relevant in vitro model of avascular tumors for anti-cancer
drug testing applications. A detailed protocol for producing both mono-culture and co-culture …

Multicellular tumor spheroids are powerful in vitro models to perform preclinical
chemosensitivity assays. We compare different methodologies to generate tumor spheroids …