Compared with traditional monolayer cell culture, the three-dimensional tumor spheroid has
emerged as an essential in vitro model for cancer research due to the recapitulation of the …

Tumor spheroid formation in microwell arrays is a promising approach for high-throughput
screening of chemotherapeutic agents. This method offers the advantage of better mimicking …

A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …

Tumor spheroids are considered a valuable three dimensional (3D) tissue model to study
various aspects of tumor physiology for biomedical applications such as tissue engineering …

Treatment of glioblastoma, the most common and aggressive type of primary brain tumors, is
a major medical challenge and the development of new alternatives requires simple yet …

Currently there is an effort toward the development of in vitro cancer models more predictive
of clinical efficacy. The onset of advanced analytical tools and imaging technologies has …

Improved in vitro models are needed to better understand cancer progression and bridge
the gap between in vitro proof-of-concept studies, in vivo validation, and clinical application …

Tumor spheroids or microtumors are important 3D in vitro tumor models that closely
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …

Three-dimensional multicellular spheroids (MCSs) have received extensive attention in the
field of biomedicine due to their ability to simulate the structure and function of tissues in vivo …

Biomaterial-based tissue culture platforms have emerged as useful tools to mimic in vivo
physiological microenvironments in experimental cell biology and clinical studies. We …