Spheroid‐on‐a‐chip platforms are emerging as promising in vitro models that enable
screening of the efficacy of biologically active ingredients. Generally, the supply of liquids to …

Creating multicellular tumor spheroids is critical for characterizing anticancer treatments
since they may provide a better model of the tumor than conventional monolayer culture …

A cell spheroid culture has the benefit of simulating in vivo three-dimensional cell
environments. Microwell systems have been developed to mass-produce large quantities of …

The development of a scalable and highly reproducible in vitro tumor microenvironment
(TME) platform still sheds light on new insights into cancer metastasis mechanisms and …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Cell-based assays can be applied to evaluate the efficiency of anti-cancer drugs but the
conventional approaches are mostly based on two-dimensional cell culture which is not able …

Cancer continues to be a leading cause of mortality in modern societies; therefore, improved
and more reliable in vitro cancer models are needed to expedite fundamental research and …

Three-dimensional in vitro spheroids are a reliable model to study tumor biology and drug
toxicity. However, inconsistencies exist in terms of seeding cell density that governs …

A facile method for generation of tumor spheroids in large quantity with controllable size and
high uniformity is presented. HCT-116 cells are used as a model cell line. Individual tumor …

Drug penetration into solid tumours remains a major challenge in the effective treatment of
cancer. Microbubble (MB) mediated sonoporation offers a potential solution to this by …