Multicellular spheroids have served as a promising preclinical model for drug efficacy testing
and disease modeling. Many microfluidic technologies, including those based on water–oil …

A major limitation with current in vitro technologies for testing anti-cancer therapies at the pre-
clinical level is the use of 2D cell culture models which provide a poor reflection of the …

Nanoparticle penetration through tumor tissue after extravasation is considered as a key
issue for tumor distribution and therapeutic effects. Most tumors possess abundant stroma, a …

ABSTRACT Three‐dimensional (3D) cell culture models of solid tumors are currently having
a tremendous impact in the in vitro screening of candidate anti‐tumoral therapies. These 3D …

Culturing and screening cells in microfluidics, particularly in three-dimensional formats, has
the potential to impact diverse areas from fundamental biology to cancer precision medicine …

Abstract 3D cell culture has been strongly advocated as a highly useful culture technique
instead of the traditional 2D cell culture. Specially, spheroids, as the primary mode of 3D cell …

Droplet microfluidic techniques have long been known as a high-throughput approach for
cell manipulation. The capacity to compartmentalize cells into picolitre droplets in …

One of the obstacles limiting progress in the development of effective cancer therapies is the
shortage of preclinical models that capture the dynamic nature of tumor microenvironments …

3D in vitro biological systems are progressively replacing 2D systems to increase the
physiological relevance of cellular studies. Microfluidics-based approaches can be powerful …

Microfluidic devices permit perfusion culture of three‐dimensional (3D) tissue, mimicking the
flow of blood in vascularized 3D tissue in our body. Here, we report a microfluidic device …