Current drugs and potential future neuroprotective compounds for Parkinson's disease

I Carrera, R Cacabelos - Current neuropharmacology, 2019 - ingentaconnect.com
The research progress of understanding the etiology and pathogenesis of Parkinson's
disease (PD) has yet lead to the development of some clinical approaches intended to treat …

[HTML][HTML] Parkinson's disease drug therapies in the clinical trial pipeline: 2020

K McFarthing, S Buff, G Rafaloff… - Journal of …, 2020 - content.iospress.com
Background: The majority of current pharmacological treatments for Parkinson's disease
(PD) were approved for clinical use in the second half of the last century and they only …

[HTML][HTML] Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

[HTML][HTML] Treatment options for motor and non-motor symptoms of Parkinson's disease

FC Church - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) usually presents in older adults and typically has both motor and
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …

[HTML][HTML] Advances in non-dopaminergic treatments for Parkinson's disease

S Stayte, B Vissel - Frontiers in neuroscience, 2014 - frontiersin.org
Since the 1960's treatments for Parkinson's disease (PD) have traditionally been directed to
restore or replace dopamine, with L-Dopa being the gold standard. However, chronic L …

[HTML][HTML] Recent advances in treating Parkinson's disease

WH Oertel - F1000Research, 2017 - ncbi.nlm.nih.gov
This article summarizes (1) the recent achievements to further improve symptomatic therapy
of motor Parkinson's disease (PD) symptoms,(2) the still-few attempts to systematically …

The scientific and clinical basis for the treatment of Parkinson disease (2009)

CW Olanow, MB Stern, K Sethi - Neurology, 2009 - AAN Enterprises
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

Updates and advances in the treatment of Parkinson disease

MW Hayes, VSC Fung, TE Kimber… - The Medical Journal of …, 2019 - mja.com.au
Updates and advances in the treatment of Parkinson disease | The Medical Journal of
Australia MJA Basic Search Advanced search search Use the Advanced search for more …

[HTML][HTML] Protection against Parkinson's disease progression: clinical experience

PA LeWitt, DC Taylor - Neurotherapeutics, 2008 - Elsevier
Treatments with potential neuroprotective capability for Parkinson's disease (PD) have been
investigated in randomized, controlled, clinical trials and other studies since the mid-1980s …

[HTML][HTML] Parkinson's disease as a system-level disorder

D Caligiore, RC Helmich, M Hallett… - npj Parkinson's …, 2016 - nature.com
Traditionally, the basal ganglia have been considered the main brain region implicated in
Parkinson's disease. This single area perspective gives a restricted clinical picture and limits …