We analyzed CYP2D6 in two individuals characterized by impaired sparteine oxidation
(intermediate metabolizer phenotype) and genotype 2D6* 2/* 4 (1661G> C; 2850C> T; …

Methods Initial PCR reactions were performed to specifically amplify exons 3, 4, 5 and 6 of
the CYP2D6 gene using primers previously published. New primers were used to identify …

Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor
metabolizer individual | SpringerLink Skip to main content Advertisement SpringerLink Log in …

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in
the 1970s. This is because of its involvement in the metabolism of more than 25% of the …

Genotyping strategies targeting allelic variants with diminished or no activity to identify poor
metabolizers generally works well in Caucasian (1–3) and Asian (4, 5) populations, but we …

Novel single nucleotide polymorphisms (SNPs) were found in introns 1, 3, 4, 5, and 7 of the
gene encoding cytochrome (CYP) 2D6 in 90 Japanese subjects. Some of these SNPs were …

A novel loss-of function allele of the CYP2D6 gene was characterized in a PM individual
using exon-by-exon PCR-SSCP analysis. This allele, we termed CYP2D6 (F), harbours four …

Abstract A subgroup of 10–15% of Caucasians are termed phenotypical 'intermediate
metabolizers' of drug substrates of CYP2D6 because they have severely impaired yet …

Two novel haplotypes of CYP2D6 were found in Japanese subjects. One haplotype of the
human CYP2D6 gene, newly designated as CYP2D6* 44 allele, had both a novel single …

Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the
metabolism of drugs. Multiple, clinically relevant, genetic variants of this gene have been …