Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing …
WS Lai, EA Kennington, PJ Blackshear - Journal of Biological Chemistry, 2002 - ASBMB
Tristetraprolin (TTP), the prototype of a small family of CCCH tandem zinc finger (TZF)
domain proteins, is a physiological stimulator of instability of the mRNAs encoding tumor …
domain proteins, is a physiological stimulator of instability of the mRNAs encoding tumor …
Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling
RS Phillips, SBV Ramos, PJ Blackshear - Journal of Biological Chemistry, 2002 - ASBMB
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind
directly to certain types of AU-rich elements (AREs) in mRNA. Experiments in TTP-deficient …
directly to certain types of AU-rich elements (AREs) in mRNA. Experiments in TTP-deficient …
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly (A) …
WS Lai, PJ Blackshear - Journal of Biological Chemistry, 2001 - ASBMB
The CCCH family of tandem zinc finger proteins has recently been shown to promote the
turnover of certain mRNAs containing class II AU-rich elements (AREs). In the case of one …
turnover of certain mRNAs containing class II AU-rich elements (AREs). In the case of one …
Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates
PJ Blackshear, WS Lai, EA Kennington… - Journal of Biological …, 2003 - ASBMB
Tristetraprolin (TTP) and its two known mammalian family members are tandem CCCH zinc
finger proteins that can bind to AU-rich elements (AREs) in cellular mRNAs and destabilize …
finger proteins that can bind to AU-rich elements (AREs) in cellular mRNAs and destabilize …
Interactions of CCCH zinc finger proteins with mRNA: binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA
WS Lai, E Carballo, JM Thorn, EA Kennington… - Journal of Biological …, 2000 - ASBMB
Macrophages derived from tristetraprolin (TTP)-deficient mice exhibited increased tumor
necrosis factor α (TNFα) release as a consequence of increased stability of TNFα mRNA …
necrosis factor α (TNFα) release as a consequence of increased stability of TNFα mRNA …
Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover
PJ Blackshear - Biochemical Society Transactions, 2002 - portlandpress.com
The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three
known members in mammals, with a fourth member recently identified in frogs and fish …
known members in mammals, with a fourth member recently identified in frogs and fish …
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
WS Lai, E Carballo, JR Strum… - … and cellular biology, 1999 - Am Soc Microbiol
Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins,
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …
develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α) …
Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover
WS Lai, DM Carrick, PJ Blackshear - Journal of Biological Chemistry, 2005 - ASBMB
Tristetraprolin (TTP), a member of the tandem CCCH zinc finger protein family, promotes
deadenylation of tumor necrosis factor-α and granulocyte-macrophage colony-stimulating …
deadenylation of tumor necrosis factor-α and granulocyte-macrophage colony-stimulating …
Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts
WS Lai, JS Parker, SF Grissom, DJ Stumpo… - … and cellular biology, 2006 - Taylor & Francis
Tristetraprolin (TTP) is a tandem CCCH zinc finger protein that was identified through its
rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice and cells derived …
rapid induction by mitogens in fibroblasts. Studies of TTP-deficient mice and cells derived …
Direct binding of specific AUF1 isoforms to tandem zinc finger domains of tristetraprolin (TTP) family proteins
VP Kedar, BE Zucconi, GM Wilson… - Journal of Biological …, 2012 - ASBMB
Tristetraprolin (TTP) is the prototype of a family of CCCH tandem zinc finger proteins that can
bind to AU-rich elements in mRNAs and promote their decay. TTP binds to mRNA through its …
bind to AU-rich elements in mRNAs and promote their decay. TTP binds to mRNA through its …