The mutational dynamics of short tandem repeats in large, multigenerational families
Abstract Background Short tandem repeats (STRs) compose approximately 3% of the
genome, and mutations at STR loci have been linked to dozens of human diseases …
genome, and mutations at STR loci have been linked to dozens of human diseases …
The sequence of the repetitive motif influences the frequency of multistep mutations in Short Tandem Repeats
S Antão-Sousa, N Pinto, P Rende, A Amorim… - Scientific Reports, 2023 - nature.com
Abstract Microsatellites, or Short Tandem Repeats (STRs), are subject to frequent length
mutations that involve the loss or gain of an integer number of repeats. This work aimed to …
mutations that involve the loss or gain of an integer number of repeats. This work aimed to …
A genomic view of short tandem repeats
M Gymrek - Current opinion in genetics & development, 2017 - Elsevier
Short tandem repeats (STRs) are some of the fastest mutating loci in the genome. Tools for
accurately profiling STRs from high-throughput sequencing data have enabled genome …
accurately profiling STRs from high-throughput sequencing data have enabled genome …
Distinct mutational behaviors differentiate short tandem repeats from microsatellites in the human genome
G Ananda, E Walsh, KD Jacob… - Genome biology and …, 2013 - academic.oup.com
A tandem repeat's (TR) propensity to mutate increases with repeat number, and can become
very pronounced beyond a critical boundary, transforming it into a microsatellite (MS) …
very pronounced beyond a critical boundary, transforming it into a microsatellite (MS) …
Population-scale sequencing data enable precise estimates of Y-STR mutation rates
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …
Profiling of short-tandem-repeat disease alleles in 12,632 human whole genomes
Short tandem repeats (STRs) are hyper-mutable sequences in the human genome. They are
often used in forensics and population genetics and are also the underlying cause of many …
often used in forensics and population genetics and are also the underlying cause of many …
Sequencing and characterizing short tandem repeats in the human genome
HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …
Genome-wide sequencing as a first-tier screening test for short tandem repeat expansions
IS Rajan-Babu, JJ Peng, R Chiu… - Genome medicine, 2021 - Springer
Background Screening for short tandem repeat (STR) expansions in next-generation
sequencing data can enable diagnosis, optimal clinical management/treatment, and …
sequencing data can enable diagnosis, optimal clinical management/treatment, and …
[HTML][HTML] WebSTR: a population-wide database of short tandem repeat variation in humans
Short tandem repeats (STRs) are consecutive repetitions of one to six nucleotide motifs.
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …
The Genomic landscape of short tandem repeats across multiple ancestries
P Vijayaraghavan, S Batalov, Y Ding, E Sanford… - Plos one, 2023 - journals.plos.org
Short Tandem Repeats (STRs) have been found to play a role in a myriad of complex traits
and genetic diseases. We examined the variability in the lengths of over 850,000 STR loci in …
and genetic diseases. We examined the variability in the lengths of over 850,000 STR loci in …