The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted.
However, the exact mechanisms linking the CD40/CD40L system and the soluble form of …

The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of
the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40 …

Abstract The CD40-CD40L system is a pathway which is associated with both prothrombotic
and proinflammatory effects. CD40 and its ligand were first discovered on the surface of …

CD40-CD40 ligand (CD40L) interactions play a central role in the development and
progression of atherosclerosis. In the late 1990s, we and others have shown that complete …

CD40 Ligand (CD40L), a member of the TNF family, was initially thought to be solely
implicated in thymus-dependent humoral responses. However, work by several groups …

Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a
stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis …

CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways
that contribute to multiple pathophysiological processes. A role for CD40–CD40L …

Atherosclerosis is a degenerative inflammatory disease of the vascular system. Endothelial
cells (ECs), smooth muscle cells, and macrophages, key elements in atherosclerosis, all …

Increasing evidence supports involvement of inflammation and immunity in atherogenesis.
We report here that CD40 ligand (CD40L), an immunoregulatory signaling molecule …

OBJECTIVE: To discuss the role of CD40 ligand (CD40L) in atherosclerosis and acute
coronary syndromes (ACS), as well as describe relevant clinical literature evaluating the …