Incidence of atherosclerosis and atherosclerosis-related complications will increase
significantly in the coming decennia. Research identified many serum and plasma markers …

Recently, we have demonstrated that human platelets carry preformed CD40 ligand
(CD154) molecules, which rapidly appear on the platelet surface following stimulation by …

Rationale: CD40L figures prominently in chronic inflammatory diseases such as
atherosclerosis. However, since CD40L potently regulates immune function and hemostasis …

CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in
immune responses via its receptor, CD40. Recently, CD40L has been detected on the …

Background Hypercholesterolemia, a risk factor for cardiovascular disease, is associated
with inflammation and hypercoagulability. Both can be mediated by the CD40 system. This …

Traditionally, platelets have been thought of as anuclear, subcellular fragments derived from
megakaryocytes circulating in blood as small discs and mitigating hemorrhage. This …

Background—Interaction of CD40L with its receptor CD40 is critically involved in
inflammatory cell activation in atherogenesis. In addition, serum levels of soluble CD40L are …

Background: Diabetes is associated with an increased risk of cardiovascular disease and
atherosclerosis. Increasing evidence shows that CD40–CD40L interaction plays a crucial …

Objective—CD40 ligand (CD154) expressed on activated T helper cells is a key
costimulatory molecule for antigen-presenting cells expressing the corresponding receptor …

Aims Inflammatory cytokines may play a pathogenic role in heart failure (HF). CD40–CD40
ligand (CD40L) interactions are important in atherogenesis and based on its role in …