The image contrast in magnetic resonance imaging (MRI) is highly sensitive to several
mechanisms that are modulated by the properties of the tissue environment. The degree and …

Diffusion imaging and bound pool fraction (BPF) mapping are two quantitative magnetic
resonance imaging techniques that measure microstructural features of the white matter of …

Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and
diffusion-based imaging can be used to characterize tissue microstructure. However …

Myelin is critical for healthy brain function. An accurate in vivo measure of myelin content
has important implications for understanding brain plasticity and neurodegenerative …

T2 weighting is particularly sensitive, but notoriously unspecific, to a wide range of brain
pathologies. However, careful measurement and analysis of the T2 decay curve from brain …

Multi-component T 2 relaxation imaging (MCRI) provides specific in vivo measurement of
myelin water content and tissue water environments through myelin water fraction (MWF) …

Multiexponential T2 relaxation time measurement in the central nervous system shows a
component that originates from water trapped between the lipid bilayers of myelin. This …

In recent years, diffusion-weighted magnetic resonance imaging (DW-MRI) has been
increasingly used to explore the relationship between white matter structure and cognitive …

In MRI, structurally aligned molecular or micro‐organization (eg axonal fibers) can be a
source of substantial signal variations that depend on the structural orientation and the …

MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a
signal dependence on the orientation of white matter (WM) fiber bundles relative to the …