Tissue distribution and left ventricular (LV) effects of digoxin were studied after intravenous
administration of low and high doses to dogs. LV dP/dt was increased by 0.03 mg/kg digoxin …

Guinea-pig and rat hearts were perfused via the aorta at constant flow with 10-7 M digoxin-
H3 for periods up to 64 min. The temperature was 28° C. The hearts were then perfused for …

Digoxin concentmtions in serum and left ventricular tissue were measured at autopsy and
related to estimated antemortem creatinine clearances in 15 patients. A significant …

Thirty-four dogs were given tritium-labeled digoxin intravenously. Serum and tissue
concentrations and half-times were determined. As demonstrated previously in human …

Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …

The effect of the shock state on myocardial digoxin uptake and plasma digoxin levels was
examined in unanesthetized dogs following hemorrhage. Five minutes after intravenous …

Postmortal tissue digoxin concentration and prefinal and postmortal plasma digoxin
concentrations from 9 patients were determined using the 125J-digoxin radioimmunoassay …

Digoxin concentration of 14 left ventricular papillary muscles and 36 right atrial appendages
of 45 patients undergoing cardiac surgery were determined by the NEN 125J …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …