Osteocytes are considered the primary mechanosensors of bone, but the signaling
pathways they apply in mechanotransduction are still incompletely investigated and …

Osteocytes reside as a cellular network throughout the mineralised matrix of bone and are
considered the primary mechanosensors of this tissue. They sense mechanical stimulation …

Mechanical loading is essential for maintaining bone health. Here, we aimed to investigate
the role of ATP and ADP in the mechanotransduction of bone-resorptive osteoclasts. Single …

Signaling between osteoblasts and osteoclasts is important in bone homeostasis. We
previously showed that human osteoblasts propagate intercellular calcium signals via two …

Extracellular nucleotides such as ATP and UTP are released in response to mechanical
stimulation in different cell systems. It is becoming increasingly evident that ATP release …

ATP is rapidly released from osteoblasts in response to mechanical load. We examined the
mechanisms involved in this release and established that shear‐induced ATP release was …

The P2 purinergic receptor family implicated in many physiological processes, including
neurotransmission, mechanical adaptation and inflammation, consists of ATP-gated non …

The P2X 7 nucleotide receptor (P2X 7 R) is an ATP-gated ion channel expressed in many
cell types including osteoblasts and osteocytes. Mice with a null mutation of P2X 7 R have …

Mechanical stimulation of osteoblasts activates many cellular mechanisms including the
release of ATP. Binding of ATP to purinergic receptors is key to load-induced osteogenesis …

Osteocytes' response to dynamic loading plays a crucial role in regulating the bone mass
but quickly becomes saturated such that downstream induction of bone formation plateaus …