Introduction: Methacholine, a derivative of acetylcholine, is a non-selective muscarinic
receptor agonist, used for the “Methacholine Challenge Test” or “Bronchoprovocation Test” …

Bronchial provocation testing has played an integral role in the diagnosis and management
of asthma for many years and provides an invaluable research tool. Inhaled methacholine …

Introduction: Bronchoprovocation inhalation challenge tests with direct acting stimuli (eg
methacholine) are widely used clinically to aid in the diagnosis of asthma. Areas covered …

Although the results of the history physical examination, and spirometry can support the
diagnosis of asthma, they are sometimes inconclusive. The methacholine inhalation …

Bronchoprovocation with the direct stimulus methacholine is a highly sensitive test (ie, has a
high negative predictive value) for asthma provided two important but sometimes overlooked …

If the diagnosis of asthma is in question, eg, if the patient has symptoms that suggest asthma
(either typical symptoms such as coughing, wheezing, and dyspnea or atypical symptoms) …

The methacholine challenge test (MCT) is a direct inhalation bronchoprovocation test used
clinically to assess airway smooth muscle (dys-) function and provides a means to both …

A variety of techniques known as bronchial provocation challenges have been developed to
determine the presence and severity of airway hyperactivity. These challenges can be used …

A 30-year-old Caucasian man presented to the pulmonary function laboratory for a
methacholine challenge test. Following inhalation of the final dose of methacholine, the …

Increased nonspecific bronchial hyperresponsiveness to pharmacologic agents such as
methacholine is a hallmark of asthma. The measurement of airway reactivity is quite …