Background Structural magnetic resonance imaging studies in individuals at clinical high
risk (CHR) for psychosis have yielded conflicting results. Methods The aims of this study …

Abstract Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity
in clinical profiles and outcome features. However, the extent of neuroanatomical …

Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Schizophrenia has a prodromal phase of several years in most patients, making it possible
to identify patients at clinical high risk (CHR) for developing the disorder. So far, these …

Several magnetic resonance imaging studies have reported reductions in hippocampal
volume in patients with psychosis. It is unclear whether structural abnormalities predate …

In subjects at risk for psychosis, the studies on gray matter volume (GMV) predominantly
reported volume loss compared with healthy controls (CON). However, other important …

Cortical volumetric asymmetry (CVA) has been widely observed in individuals with
psychosis, and is associated with etiological risk factors (eg, genetics, neuromaturation) and …

Reduction in hippocampal volume is a hallmark of schizophrenia and already present in the
clinical high-risk state. Nevertheless, other subcortical structures, such as the thalamus …

BACKGROUND: Hippocampal volume (HV) reduction is well documented in schizophrenia.
However, it is still unclear whether this change is a pre-existing vulnerability factor, a sign of …

Previous studies have reported alterations in grey matter volume and cortical thickness in
individuals at high risk of developing psychosis and patients in the early stages of the …