The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the
cell cycle and inactivation of the gene has been found in a variety of human cancers. In …

Abstract BACKGROUND The p16INK4A gene encodes 2 cell cycle regulator proteins, p16
and p14ARF, by alternative splicing. This genetic locus also contains another cell cycle …

We analyzed the p16INK4 status of 6 hepatocellular carcinoma (HCC) cell lines and 32
primary HCC tumors, including 9 early‐stage tumors, to determine whether p16INK4 tumor …

Background & Aims: The molecular status of the p16INK4 tumor-suppressor gene has not
been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the …

We examined the genomic status of the p16INK4A (inhibitor of cyclin‐dependent kinase 4 A)
and cyclin‐dependent kinase 4 (CDK4) genes in 62 human hepatocellular carcinomas …

BACKGROUND Inactivation of the tumour suppressor gene p16 (CDKN2/MTS-1/INK4A) and
K-ras mutations are among the most frequent genetic alterations in human malignancies …

The molecular mechanisms of hepatocarcinogenesis are poorly understood. Only very
recently has there been a suggestion of familial hepatocellular carcinoma (HCC). We have …

Purpose: The tumor suppressor gene p16INK4A is mainly inactivated by an epigenetic
change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical …

It is known that p16INK4 tumor suppressor gene expression in colon cancer cells is
repressed by methylation at the CpG island of promoter, but in vivo silencing of p16 gene is …

AIM: To study the significance of p16 and p15 transcription suppression with
hypermethylation of their genes'5'CpG islands during human hepatocellular carcinogenesis …